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Merck and Moderna melanoma drug combo cuts recurrence risk by 42%
Company News

Merck and Moderna melanoma drug combo cuts recurrence risk by 42%

INVESTING.COM

Merck (MRK) and Moderna (MRNA) announced Phase 3 trial results showing that intismeran autogene combined with KEYTRUDA (pembrolizumab) reduced the risk of recurrence or death by 42% compared to KEYTRUDA alone in patients with completely resected stage IIB-IV melanoma.

The INTerpath-001 trial enrolled 1,137 patients who were randomized 2:1 to receive intismeran plus KEYTRUDA or placebo plus KEYTRUDA for approximately one year. After a median follow-up of 24.6 months, the combination also reduced the risk of distant metastasis or death by 38% compared to KEYTRUDA alone. The two-year recurrence-free survival rate was 82.2% for the combination versus 70.0% for KEYTRUDA alone.

A pre-specified sensitivity analysis found that after the six-month intismeran immunization regimen was completed, the combination reduced the risk of recurrence or death by 58% compared to KEYTRUDA alone. During the first six months, efficacy was comparable between the two arms.

Overall survival data are not yet m

Auna stock tumbles as company slashes 2026 EBITDA guidance
Company News

Auna stock tumbles as company slashes 2026 EBITDA guidance

STREETINSIDER.COM

Investing.com --Auna SAA ADR (NYSE: AUNA) fell 15.7% in premarket trading Thursday after the Latin American healthcare company cut its 2026 EBITDA outlook due to cost pressures from a Colombia payor contract.

The company now expects consolidated Adjusted EBITDA to be broadly stable YoY, a sharp downgrade from its previous guidance of 10% to 14% FX-neutral growth. The revision stems from unexpected high incidence of advanced-stage cancer cases within a covered population under a specific payor contract in Colombia, creating additional temporary cost pressure.

Auna maintained its full-year 2026 revenue guidance of around 12% FX-neutral growth, supported by continued strong recovery in Mexico during the second half of the year. The company said its revenue outlook remains consistent with recently disclosed operating KPIs that reflect favorable volume and specialty service trends in the third quarter of 2026.

Capital expenditures remain within previously communicated guidance of approxi

Nasdaq posts worst day since June as AI financing worries batter risk sentiment
Market Summary

Nasdaq posts worst day since June as AI financing worries batter risk sentiment

INVESTING.COM

Investing.com -- Wall Street saw a classic risk-off trading session on Thursday, as investors dumped high-growth communication services and technology stocks and flocked to the safety of defensive sectors and safe-haven U.S. Treasuries.

The artificial intelligence trade suffered, with chip stocks notching their worst day since June 23. Meta Platforms led AI hyperscalers lower, after the social media behemoth indicated a slight rise in capital spending forecasts and announced the establishment of a new class of nonvoting stock to raise capital for its AI ambitions.

Meanwhile, oil prices marched higher after fresh attacks by Iran-backed Houthis on Saudi Arabian energy facilities and airports stoked supply disruption fears.

The benchmark S&P 500 dropped 1.2% to close at 7,664.99 points, while the blue-chip Dow Jones Industrial Average ended flat at 52,866.85 points. The tech-heavy NASDAQ Composite was the hardest hit, dumping 2.6% to settle at 26,008.86 points, and posting its worst in

J.P. Morgan backs Benelux insurers on valuation discount, shareholder returns
Analyst & Opinion

J.P. Morgan backs Benelux insurers on valuation discount, shareholder returns

STREETINSIDER.COM

Investing.com -- J.P. Morgan upgraded Dutch insurer ASR Nederland and insurer Ageas to "overweight" from "neutral" because Benelux insurers trade at about 8.5 times expected 2027 earnings, against about 11.5 times for European insurers.

The broker raised its December 2027 price target on ASR to €90 from €80 and on Ageas to €90 from €80. ASR shares closed at €74.58 and Ageas at €74.95 on Oct 21.

The broker forecast annual earnings-per-share growth of 7% to 9% for the sector over 2026-29, and said Benelux insurers offer high single-digit to double-digit returns to shareholders through dividends and buybacks.

It called ASR the most direct listed beneficiary of Dutch pension reform, citing its sole exposure to the Dutch insurance market and larger pensions business after buying Aegon Netherlands.

The reform shifts pensions from guaranteed-benefit schemes to defined contribution plans, with legislation taking effect on Jan 1, 2028.

J.P. Morgan expects ASR to announce higher capital ret

Sellers are back in tech, while bear market grips Chinese stocks
Market Summary

Sellers are back in tech, while bear market grips Chinese stocks

CNBC.COM

In this article

This is CNBC’s Morning Squawk newsletter. Subscribe here to receive future editions in your inbox.

Hello, this is Leonie Kidd with today’s edition of Morning Squawk.

The pickup in volume during super early trading has been overwhelmingly to the downside.

Futures are worse, Asia closed deep in the red, and Europe is also broadly lower.

It seems the all-or-nothing approach to tech continues...

Futures are steadily declining this morning, with chip stocks once again under pressure.

The earnings handover from Wall Street was mixed, but investors seem more hung up on Tesla’s disappointing forecasts than Meta’s beat.

Tesla round-up: Better-than-expected third-quarter results are failing to support Tesla shares, with the stock falling in premarket trading. Lower average car sales prices and a battery supply crunch weighed on revenues.

Musk also warned the group is “not going to move the needle” on its Robotaxi fleet this quarter.

Meta round-up: Shares in Meta have al

Lawsuit accuses Trump of illegally profiting off foreign crypto deals
Company News

Lawsuit accuses Trump of illegally profiting off foreign crypto deals

CNBC.COM

In this article

A lawsuit filed Thursday accuses President Donald Trump and his family’s crypto company of “corruptly profiting” off more than $2 billion in digital currency-related deals, violating constitutional restrictions on accepting foreign money.

“No president in American history has profited from his office so brazenly,” alleges the federal civil complaint from a shareholder of Circle Internet Group, a publicly traded U.S. crypto company and competitor of the Trump family business, World Liberty Financial.

The suit filed in U.S. District Court in Washington by shareholder and former Circle employee J. Benjamin Greenberg centers on two allegedly “illegal foreign emoluments” involving World Liberty and Sheikh Tahnoon bin Zayed Al Nahyan, the national security advisor to the United Arab Emirates.

Days before Trump’s inauguration in January 2025, an entity backed by Tahnoon — widely known as the “Spy Sheikh” because of his powerful intelligence role — agreed to buy a 49% stake

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New US unemployment claims fell to 194,000 last week, with the 4-week average at 197,750 – the lowest levels since 1969 . This 'low-hire, low-fire' labor market signals stability but also potential stagnation. The data reinforces the Federal Reserve's challenge in balancing its dual mandate of low inflation and low unemployment, potentially supporting continued interest rate hikes .

Unemployment Lines Are Shorter Than Any Time Since The 1960s

Unemployment Lines Are Shorter Than Any Time Since The 1960s

INVESTOPEDIA.COMOct 22, 9:06 PM UTC
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The AI-related technology sector continues its broad retreat, with Celestica (CAD) shares tumbling 11.5% today amid pre-earnings risk reduction, insider selling, and a bearish technical pattern . The NASDAQ fell 2.6% as investors dumped AI names, including Nvidia, AMD, Broadcom, and Marvell Technology .

Even strong earnings reports are not immune: Western Digital (WDC) initially surged 4% after beating Q1 estimates and providing upbeat guidance, but subsequently erased all gains as the AI selloff extended . This indicates a strong bearish sentiment overriding positive company-specific news.

Key points:

  • Celestica (CAD): Down 11.5% on AI tech selloff, pre-earnings caution, insider sales.
  • Western Digital (WDC): Q1 beat and strong guidance negated by sector-wide selling.
  • Broader Impact: NASDAQ down 2.6%, with major AI players retreating .
Why is Celestica stock tumbling today?

Why is Celestica stock tumbling today?

INVESTING.COMOct 22, 7:07 PM UTC
Western Digital beats earnings estimates, but AI selloff erases initial gains

Western Digital beats earnings estimates, but AI selloff erases initial gains

STREETINSIDER.COMOct 22, 8:13 PM UTC
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Freedom Broker has issued a sweeping downgrade across major North American gold producers, citing trimmed EBITDA forecasts, operational risks, and valuation constraints. This led to significant share price drops:

  • Agnico Eagle (AEM): Downgraded to Hold, PT cut to $212 (from $255) on valuation premium and revised 2027 EBITDA.
  • Barrick Mining (B): Downgraded to Hold, PT cut to $46 (from $54) due to near-term earnings estimate reductions.
  • Newmont (NEM): Downgraded to Hold, PT cut to $116 (from $130) on cost inflation and performance risks.

RBC Capital Markets also noted gold producers face margin pressure in Q3 from lower gold prices and elevated costs, despite expected production improvements .

Agnico, Barrick, and Newmont fall following broad Freedom Broker downgrades

Agnico, Barrick, and Newmont fall following broad Freedom Broker downgrades

STREETINSIDER.COMOct 22, 2:56 PM UTC
Gold miners face margin pressure as lower prices complicate third-quarter results

Gold miners face margin pressure as lower prices complicate third-quarter results

STREETINSIDER.COMOct 22, 7:58 PM UTC
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US stock futures and major indices are sharply lower, led by a broad sell-off in the tech sector. Concerns over the long-term sustainability of AI infrastructure spending and rising borrowing costs are weighing on sentiment . Chip stocks, including Marvell Technology (-5%), Micron, Sandisk, Seagate, and Western Digital, are under pressure . Mega-cap tech names like Meta Platforms (-7%) and Tesla (-5.2%) are also declining despite mixed earnings reactions .

Key points:

  • AI Spending Doubts: Warnings from chip executives about capital access becoming a constraint on AI expansion and clouding ROI .
  • Broad Tech Weakness: Nasdaq Composite down 2.2%, S&P 500 down 1.2% .
  • Geopolitical Headwinds: Oil prices surge on Middle East escalations, contributing to a broad risk-off tone .
  • Memory Glut Fears: Nvidia CEO Jensen Huang attempts to counter concerns about a 2029 memory glut, but memory stocks remain under pressure .
Why is Marvell Technology stock sliding today?

Why is Marvell Technology stock sliding today?

INVESTING.COMOct 22, 1:46 PM UTC
Stock Market Today: Nasdaq, S&P 500 Dive, Led Lower by Tech Stocks; Oil Prices Surge on Middle East Escalations; 10-Year Yield Sinks Below 5%

Stock Market Today: Nasdaq, S&P 500 Dive, Led Lower by Tech Stocks; Oil Prices Surge on Middle East Escalations; 10-Year Yield Sinks Below 5%

INVESTOPEDIA.COMOct 22, 4:45 PM UTC
Sellers are back in tech, while bear market grips Chinese stocks

Sellers are back in tech, while bear market grips Chinese stocks

CNBC.COMOct 22, 11:50 AM UTC
JPMorgan says tech stocks lead U.S. futures lower on risks

JPMorgan says tech stocks lead U.S. futures lower on risks

STREETINSIDER.COMOct 22, 12:50 PM UTC
Nvidia’s Jensen Huang says he sees no sign of a 2029 memory glut: ‘You can always use more’

Nvidia’s Jensen Huang says he sees no sign of a 2029 memory glut: ‘You can always use more’

CNBC.COMOct 22, 1:12 PM UTC
Tech Slump Hits Memory, Data Storage Stocks With Western Digital Earnings Due Later Today

Tech Slump Hits Memory, Data Storage Stocks With Western Digital Earnings Due Later Today

INVESTOPEDIA.COMOct 22, 3:00 PM UTC
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The tech sector is facing significant headwinds today, with a broad sell-off impacting chip stocks and AI-linked companies. Concerns over the long-term sustainability of AI infrastructure spending and rising borrowing costs are rattling investor confidence .

Key movements:

  • Marvell Technology (MRVL) slid 5.0% as optical communications and AI-linked semiconductor stocks faced coordinated risk-off pressure .
  • Tesla (TSLA) fell 5.2% in premarket trading despite better-than-expected Q3 results, weighed down by lower average car sales prices and a battery supply crunch .
  • Meta Platforms (META) reversed initial gains to trade down 2% following its earnings report .
  • Nvidia (NVDA) declined 2.4% , though CEO Jensen Huang dismissed concerns of a 2029 memory glut, stating 'you can always use more' .

The NASDAQ fell 1.5%, reflecting a broader risk-off sentiment across U.S. equities .

Sellers are back in tech, while bear market grips Chinese stocks

Sellers are back in tech, while bear market grips Chinese stocks

CNBC.COMOct 22, 11:50 AM UTC
Why is Marvell Technology stock sliding today?

Why is Marvell Technology stock sliding today?

INVESTING.COMOct 22, 1:46 PM UTC
Nvidia’s Jensen Huang says he sees no sign of a 2029 memory glut: ‘You can always use more’

Nvidia’s Jensen Huang says he sees no sign of a 2029 memory glut: ‘You can always use more’

CNBC.COMOct 22, 1:12 PM UTC
JPMorgan says tech stocks lead U.S. futures lower on risks

JPMorgan says tech stocks lead U.S. futures lower on risks

STREETINSIDER.COMOct 22, 12:50 PM UTC
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Nvidia CEO Jensen Huang states demand for neocloud firms is 'off the charts,' but scarce working capital is holding back growth. Huang noted that the demand for capital far exceeds its availability, a bottleneck he expects to be resolved. Nvidia is actively investing in Europe's AI sector to kickstart the economy there .

Key takeaways:

  • Strong AI Demand: Confirms robust underlying demand for AI infrastructure.
  • Capital Constraint: Highlights a potential funding challenge for scaling AI capabilities.
  • Nvidia's Role: Company actively investing to foster AI ecosystem growth.
Nvidia CEO Jensen Huang says neocloud demand is ‘off the charts’ but capital is scarce

Nvidia CEO Jensen Huang says neocloud demand is ‘off the charts’ but capital is scarce

CNBC.COMOct 22, 10:19 AM UTC
2

IBM shares surged 6% after reporting a clean Q3 top- and bottom-line beat. The IT services and hybrid cloud leader posted adjusted EPS of $2.95 (vs. $2.86 est.) on revenue of $17.1 billion (vs. $16.82 billion est.) .

Key takeaways:

  • Reaffirmed full-year constant-currency revenue growth target of 4% to 5%.
  • Driven by expanding Red Hat adoption and growing enterprise AI consulting bookings.

This indicates continued momentum in its strategic growth areas.

After-Hours Movers: META, IBM, TSLA, LRCX, KLAC, AMAT, CSX, KMI, LVS

After-Hours Movers: META, IBM, TSLA, LRCX, KLAC, AMAT, CSX, KMI, LVS

INVESTING.COMOct 21, 8:35 PM UTC
2

Meta Platforms (META) shares surged 7% after reporting Q3 results that exceeded expectations and providing robust Q4 revenue guidance. The company posted Q3 EPS of $3.83 (vs. $3.57 est.) on revenue of $64.60 billion (vs. $63.33 billion est.). Q4 revenue is projected at $73-76 billion, above consensus .

Key takeaways:

  • AI Investment: Meta raised its full-year expense outlook and narrowed capital expenditures to $135-145 billion, signaling continued heavy investment in AI infrastructure .
  • New Share Class: The board approved a new publicly listed, non-voting Class C common stock, effective Jan 2027. This is intended to provide flexibility for capital raising, employee compensation, and acquisitions without diluting CEO Zuckerberg's voting control .
  • Engagement: CEO Mark Zuckerberg noted all-time high engagement on Facebook and Instagram .
Meta beats Q3 estimates, approves new nonvoting share class as AI spending surges

Meta beats Q3 estimates, approves new nonvoting share class as AI spending surges

INVESTING.COMOct 21, 8:48 PM UTC
After-Hours Movers: META, IBM, TSLA, LRCX, KLAC, AMAT, CSX, KMI, LVS

After-Hours Movers: META, IBM, TSLA, LRCX, KLAC, AMAT, CSX, KMI, LVS

INVESTING.COMOct 21, 8:35 PM UTC
Meta eyes nonvoting shares to help fund AI spending, Semafor reports

Meta eyes nonvoting shares to help fund AI spending, Semafor reports

STREETINSIDER.COMOct 21, 7:44 PM UTC
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Meta Platforms (META) is reportedly considering issuing non-voting shares to finance its substantial AI investments without diluting CEO Mark Zuckerberg's voting control . This potential move, which could be announced with Q3 earnings today, mirrors Alphabet's structure and aims to provide capital flexibility for AI infrastructure and acquisitions .

Key points:

  • Funding AI: Strategy to raise billions for AI without impacting Zuckerberg's control.
  • Earnings Catalyst: Announcement could coincide with Q3 earnings report after market close .
  • Market Sentiment: Shares rose today ahead of earnings, with bullish options activity noted .
  • Risk: Potential dilution of existing shareholders' economic interests .

Investors will be watching closely for details on Meta's AI spending plans and any share issuance strategy alongside its Q3 results.

Meta eyes nonvoting shares to help fund AI spending, Semafor reports

Meta eyes nonvoting shares to help fund AI spending, Semafor reports

STREETINSIDER.COMOct 21, 7:44 PM UTC
Tech Earnings Today: Tesla, Meta Shares Finish Higher With Results Due After Close

Tech Earnings Today: Tesla, Meta Shares Finish Higher With Results Due After Close

INVESTOPEDIA.COMOct 21, 8:07 PM UTC
Meta and Tesla bulls get confidence boost after SpaceX earnings

Meta and Tesla bulls get confidence boost after SpaceX earnings

CNBC.COMOct 21, 4:35 PM UTC
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Nvidia is significantly expanding its AI supply chain, driving major gains for partners. Amkor Technology (AMKR) surged 8% after announcing an expanded advanced packaging partnership with Nvidia in South Korea, targeting a 300% increase in interposer wafer capacity by 2028 . This move is part of Nvidia's broader strategy to scale global manufacturing capacity across multiple partners to meet surging AI demand .

Separately, Moody's upgraded Taiwan Semiconductor Manufacturing Co's (TSM) issuer rating to Aa2 from Aa3, citing its dominant market share and persistent demand for AI applications. TSM reported a 51% YoY revenue surge in Q3 2026, with advanced nodes accounting for 79% of wafer revenue .

Amkor Technology stock jumps on Nvidia advanced packaging expansion

Amkor Technology stock jumps on Nvidia advanced packaging expansion

STREETINSIDER.COMOct 21, 11:47 AM UTC
Moody’s upgrades TSMC rating to Aa2 on booming AI demand and market dominance

Moody’s upgrades TSMC rating to Aa2 on booming AI demand and market dominance

STREETINSIDER.COMOct 21, 4:34 PM UTC
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