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Merck KGaA to acquire Silence Therapeutics for $1.3 billion
Company News

Merck KGaA to acquire Silence Therapeutics for $1.3 billion

INVESTING.COM

LONDON - Silence Therapeutics plc (NASDAQ:SLN) announced today that it has entered into a definitive agreement to be acquired by Merck KGaA, Darmstadt, Germany in an all-cash transaction valued at approximately $1.3 billion in equity value and $1.1 billion in enterprise value, according to a press release statement.

Under the terms of the agreement, Silence shareholders will receive $20.00 in cash per American Depositary Share, with each ADS representing three ordinary shares. The offer represents a 130% premium to Silence’s closing ADS price on Friday and an 82% premium to the 30-day volume-weighted average price of $10.99.

The transaction will be effected through a U.K. scheme of arrangement under Part 26 of the UK Companies Act 2006. The deal is expected to close in the first quarter of 2027, subject to Silence shareholder approval, sanction by the High Court of Justice of England and Wales, and other customary closing conditions including regulatory approvals.

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Indonesian stocks plunge to six-year low as MSCI downgrade fears mount
Market Summary

Indonesian stocks plunge to six-year low as MSCI downgrade fears mount

CNBC.COM

In this article

Indonesia’s benchmark stock index plunged over 5% on Monday to its lowest level in six years, as concerns over a potential downgrade by MSCI intensified fears of further foreign investor outflows.

The Jakarta Composite Index tumbled to its lowest level since early October 2020, extending a bruising sell-off in Indonesian equities. MSCI, the index provider, on Friday proposed reclassifying Indonesia directly from an emerging market to stand-alone status, raising the prospect of the country’s removal from major global equity benchmarks.

MSCI is expected to make a final decision by June, with the potential reclassification hinging on whether Indonesian authorities can demonstrate meaningful improvements in market governance and transparency.

Goldman Sachs warned in a Sunday note that a full removal from MSCI’s emerging-market indexes could trigger approximately $5.6 billion in passive fund outflows, equivalent to 18 days of average daily trading volume for constituents

LiveRamp stock rises as FTC clears Publicis acquisition
Company News

LiveRamp stock rises as FTC clears Publicis acquisition

STREETINSIDER.COM

Investing.com -- Liveramp Holdings Inc (NYSE: RAMP) shares rose 2% Monday after the Federal Trade Commission approved Publicis Groupe SA's (EPA: PUBP) $2.2 billion acquisition of the company with conditions designed to preserve competition in the digital advertising market.

The FTC issued a consent order requiring Publicis to maintain neutral and nondiscriminatory access to LiveRamp's products and services and establish firewalls to prevent Publicis from accessing LiveRamp's customer data. The regulatory approval removes a key hurdle for the deal, which was announced in May at $38.50 per share.

The FTC's complaint raised concerns that Publicis's acquisition of LiveRamp, which provides data connectivity services for digital advertising, would harm competition in markets for media agency services and audience data services. The agency alleged that the deal would give Publicis the ability to foreclose customers of competing media agencies by leveraging control of LiveRamp to pressure cl

Jefferies downgrades Eyepoint stock rating on trial miss
Company News

Jefferies downgrades Eyepoint stock rating on trial miss

INVESTING.COM

Investing.com - Jefferies downgraded EyePoint Inc. (NASDAQ:EYPT) to Hold from Buy and cut its price target to $1.00 from $8.00 on Monday. The stock plummeted to $0.45, down 86% from its previous close of $3.14, with shares now trading near their 52-week low and down 84% year-to-date.

The downgrade follows the company’s Phase 3 LUCIA study of Duravyu in wet age-related macular degeneration missing its primary endpoint of best corrected visual acuity non-inferiority to aflibercept. This marks the second Phase 3 trial setback after the LUGANO study also missed its endpoint.

EyePoint stated no study irregularities impacted the results and there are no meaningful subgroup differences. The company plans to analyze the results further, but Jefferies said a path forward in wet age-related macular degeneration appears unlikely.

The company’s Phase 3 diabetic macular edema program is fully enrolled with data expected in the fourth quarter of 2027. EyePoint reported cash of $118 million, or $1

Cleveland-Cliffs Stock Jumps on Rosy Outlook
Company News

Cleveland-Cliffs Stock Jumps on Rosy Outlook

INVESTOPEDIA.COM

Get personalized, AI-powered answers built on 27+ years of trusted expertise.

A rosy outlook has investors piling into shares of steel producer Cleveland-Cliffs.

Shares of Cleveland-Cliffs (CLF) were up over 14% in premarket trading, after the steelmaker’s adjusted EBITDA projections easily topped analysts’ expectations.

The company said it sees adjusted EBITDA of about $715 million for the fourth quarter of 2026, above the $683.6 million analysts surveyed by Visible Alpha called for. Cleveland-Cliffs projected 2027 adjusted EBITDA exceeding $4 billion, easily outdistancing the $2.54 billion consensus estimate.1

“We expect fourth quarter adjusted EBITDA to further increase, even with typical fourth-quarter seasonality and planned maintenance outages,” Cleveland-Cliffs CEO Lourenco Goncalves said. “We continued to reduce debt in Q3 and, with amplified free cash flow in Q4 and property sale proceeds, we expect a major debt reduction in the fourth quarter.”

In the third quarter, the

XBiotech’s cancer drug meets trial survival target
Company News

XBiotech’s cancer drug meets trial survival target

INVESTING.COM

AUSTIN, Texas - XBiotech Inc. (NASDAQ:XBIT) announced today that its Phase II TASKIN clinical trial met its primary efficacy endpoint, with 61.3% of patients in the experimental arm surviving at 12 months.

The investigator-sponsored study, funded by the French National Cancer Institute and coordinated by Centre Georges-François Leclerc in Dijon, France, evaluated XBiotech’s anti-IL-1α monoclonal antibody XB2001 (vilamakitug) combined with standard chemotherapy in patients with refractory metastatic colorectal cancer.

The trial enrolled 159 evaluable patients randomized to receive either vilamakitug or placebo plus standard-of-care trifluridine/tipiracil with or without bevacizumab. At 12 months, 49 of 80 patients (61.3%) in the vilamakitug arm were alive, surpassing the protocol-defined threshold of 42 patients required to establish efficacy. The control arm showed 44 of 79 patients (55.7%) alive at 12 months.

Median progression-free survival was 5.9 months for the vilamakitug arm v

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Concerns are mounting over the financial health of AI infrastructure providers. S&P Global warns that top hyperscalers likely have more AI-linked debt than currently known, citing 'interconnected financing structures' and projecting negative free cash flow for major players until at least next year .

This comes as CoreWeave, a key AI cloud provider, sees its unsecured bonds yield ~15% and 5-year credit default swaps trade above 1100 basis points, impacting partners like Galaxy Digital . Meanwhile, Nscale is in talks for a massive $45 billion computing deal with Anthropic, but investors are scrutinizing the economics of such debt-funded expansions .

Top hyperscalers likely to have more AI-linked debt than now known, S&P Global warns

Top hyperscalers likely to have more AI-linked debt than now known, S&P Global warns

INVESTING.COMOct 19, 4:18 PM UTC
StoneX reiterates Galaxy Digital stock rating on tenant concerns

StoneX reiterates Galaxy Digital stock rating on tenant concerns

INVESTING.COMOct 19, 2:50 PM UTC
Nscale in talks for $45 billion Anthropic AI deal as IPO looms

Nscale in talks for $45 billion Anthropic AI deal as IPO looms

STREETINSIDER.COMOct 19, 7:46 PM UTC
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The biotech sector is experiencing significant volatility following key clinical trial readouts:

  • Disc Medicine (IRON) surged 60% after its Phase 3 APOLLO trial for erythropoietic protoporphyria (EPP) met all primary and secondary endpoints .
  • Veradermics (MANE) rose 6.7% premarket as its oral hair loss drug VDPHL01 met all Phase 3 goals .
  • Conversely, EyePoint (EYPT) plummeted 86% after its Phase 3 wet AMD study missed its primary endpoint, leading Jefferies to downgrade the stock to Hold with a reduced price target .

These results highlight the high-stakes nature of clinical development and its immediate impact on biotech valuations.

Disc Medicine surge 60% on positive Phase 3 trial for rare sunlight disorder

Disc Medicine surge 60% on positive Phase 3 trial for rare sunlight disorder

STREETINSIDER.COMOct 19, 11:53 AM UTC
Veradermics stock surges as hair loss drug meets Phase 3 goals

Veradermics stock surges as hair loss drug meets Phase 3 goals

STREETINSIDER.COMOct 19, 1:24 PM UTC
Jefferies downgrades Eyepoint stock rating on trial miss

Jefferies downgrades Eyepoint stock rating on trial miss

INVESTING.COMOct 19, 2:50 PM UTC
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Disc Medicine (NASDAQ: IRON) shares surged 60% premarket after its Phase 3 APOLLO trial for bitopertin, an investigational treatment for erythropoietic protoporphyria (EPP), met all primary and secondary endpoints .

Key highlights:

  • Reduced Toxic Buildup: 41.4% reduction in whole-blood metal-free protoporphyrin IX.
  • Increased Light Exposure: Patients gained 12.2 hours of pain-free light exposure monthly.
  • Improved Safety: Generally well-tolerated with mild/moderate dizziness as the most common side effect.

The company plans to resubmit a New Drug Application (NDA) to the FDA by end of 2026, with a regulatory decision anticipated by mid-2027 .

Disc Medicine surge 60% on positive Phase 3 trial for rare sunlight disorder

Disc Medicine surge 60% on positive Phase 3 trial for rare sunlight disorder

STREETINSIDER.COMOct 19, 11:53 AM UTC
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Social unrest and political instability in France are impacting European assets. The CAC 40 index is down nearly 1%, and the French 10-year bond yield jumped 7 basis points, nearing multi-decade highs. The euro also fell 0.15% against the dollar . Concerns about France's fiscal outlook and the widening 'OAT-Bund spread' are raising fears of higher borrowing costs and tighter regulation, with French yields now surpassing Italy or Greece .

French unrest compounds debt crisis fears. Paris-listed stocks, bonds and the euro fall

French unrest compounds debt crisis fears. Paris-listed stocks, bonds and the euro fall

CNBC.COMOct 19, 9:07 AM UTC
France concerns weigh on Europe, while Wall Street looks to AI earnings

France concerns weigh on Europe, while Wall Street looks to AI earnings

INVESTING.COMOct 19, 9:30 AM UTC
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Oil prices are down in early Asian trade after US President Donald Trump waived sanctions and tariffs on Russia. The move could lead to increased Russian fuel exports, easing supply concerns.

  • Brent crude futures fell $1.06 (-0.96%) to $108.80/barrel.
  • US WTI crude was down $0.23 (-0.23%) to $101.18/barrel.

This development follows Friday's settlement where Brent hit its highest since May 19.

Oil slips as Trump’s sanction waiver may lead to more Russian fuel supplies

Oil slips as Trump’s sanction waiver may lead to more Russian fuel supplies

INVESTING.COMOct 18, 10:24 PM UTC
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India's Finance Minister Nirmala Sitharaman attributes the equity market's 12% YTD underperformance to excess liquidity and easy investor exits . Foreign investors have pulled over $33 billion from Indian equities this year, with capital increasingly flowing towards AI and US markets . While domestic inflows remain strong, continued foreign capital outflows are identified as a significant risk for 2027 .

India’s Finance Minister blames easy exits and excess liquidity for equity market’s underperformance

India’s Finance Minister blames easy exits and excess liquidity for equity market’s underperformance

CNBC.COMOct 18, 11:00 PM UTC
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Romanian F-16 jets shot down two suspected Russian Geran-4 drones over its territorial waters, marking the first such incident for the NATO member . The drones, flying at 450 km/h, follow recent attacks on chemical tankers near Romania's Black Sea coast, highlighting escalating risks to commercial shipping . NATO officials confirm readiness to respond, with the North Atlantic Council scheduled to meet to discuss Black Sea defense and deterrence. This incident signals heightened geopolitical tensions and potential implications for regional shipping and security .

Romanian F-16 fighter jets shoot down two drones over Romanian territorial waters

Romanian F-16 fighter jets shoot down two drones over Romanian territorial waters

INVESTING.COMOct 18, 2:00 PM UTC
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Despite Prime Minister Mark Carney's push for a new pipeline to boost Canadian oil production and exports, the initiative is unlikely to revive the sector's job boom. Automation and efficiency gains are projected to lead to a 4% decline in oil sands employment by 2035, even as production grows by 6% . This trend highlights a significant disconnect between output growth and job creation, posing political challenges for Carney and potentially fueling Alberta's separatist movement .

Analysis-Carney’s pipeline push is unlikely to bring back Canada’s oil jobs boom

Analysis-Carney’s pipeline push is unlikely to bring back Canada’s oil jobs boom

INVESTING.COMOct 18, 12:37 PM UTC
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China's Ministry of Commerce has proposed export restrictions on 12 critical solar manufacturing technologies, citing national security concerns . This move could significantly impact global solar production plans and solidify Beijing's leading position in the photovoltaic industry .

Key details:

  • Prohibited Exports: Technologies for thin silicon wafers, perovskite/tandem solar cells, and large-scale fluidised-bed polysilicon production .
  • Restricted Exports: Advanced solar cell manufacturing technologies including TOPCon, HJT, and XBC .
  • Impact: Could complicate efforts by overseas manufacturers, including companies like Tesla, to expand domestic solar production outside China .

This policy aims to prevent uncontrolled technology outflow and maintain China's strategic advantage in the solar supply chain.

China proposes export curbs on 12 key solar manufacturing technologies

China proposes export curbs on 12 key solar manufacturing technologies

INVESTING.COMOct 18, 8:06 AM UTC
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US President Trump has waived key sanctions and tariffs on Russia, including duties on goods and penalties for buying its oil and gas, just days before they were set to take effect under the Graham Act .

  • Policy Shift: The executive order reverses measures aimed at increasing pressure on Russia for its invasion of Ukraine.
  • Ukrainian Reaction: President Zelenskiy criticized the move as 'wrong,' stating it 'definitely helps only the Russians' and 'fuels their satisfaction and their desire to keep killing people' .
  • Russian Response: Russia's investment envoy called the waiver 'a truly historic moment,' noting it prevents a halt to economic cooperation .

This development signals a significant shift in US policy towards Russia, potentially impacting energy markets and geopolitical dynamics.

Zelenskiy criticizes Trump’s waiver of sanctions on Russia as ’wrong’

Zelenskiy criticizes Trump’s waiver of sanctions on Russia as ’wrong’

INVESTING.COMOct 17, 10:36 PM UTC
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