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After-Hours Movers:

Alphabet (GOOGL)

Alphabet rose 2% in post-market trading after Google unveiled Gemini 4 Argon, its next-generation flagship AI model. The release follows weeks of anticipation and signals accelerated model deployment across Google Cloud and enterprise AI workflows, boosting investor sentiment around Alphabet’s proprietary AI stack and infrastructure positioning.

Micron Technology (MU)

Micron Technology jumped 2% after delivering a massive fiscal Q4 beat-and-raise report.

Investing.com -- Bernstein has identified top investment opportunities in the U.S. networking and communications equipment sector, with Celestica emerging as the firm's highest-conviction pick among a select group of companies positioned to benefit from data center infrastructure buildouts.

The research firm highlighted three stocks with Outperform ratings, citing growth opportunities in optical modules, switching infrastructure, and artificial intelligence hardware deployment. The analysts pro

Investing.com -- Today is shaping up to be a landmark day for Synopsys Inc (SNPS) amid the announcement of two major deals. The market is rewarding the stock with a +4.97% move to $435.70 (as of Sep 30, 3:41 PM EDT), with an intraday high of $445.57.

The headline: Amazon.com (AMZN)’s AWS has signed a $1B+ multi-year agreement to license Synopsys’ silicon intellectual property (IP) for custom chip development — covering its Nitro, Graviton, and Trainium processors. Read more

Several structural

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Hewlett Packard Enterprise shares rallied to a record high after the networking hardware maker raised its growth targets and said it struck a big server deal.

Shares of HPE (HPE) were up 5% in recent trading to $65, leaving them on track to top last week’s record close, after reaching an intraday high at $67. It was one of the biggest gainers in the S&P 500 Wednesday.

At the company’s annual investor day, HPE said i

After-Hours Movers:

Alphabet (GOOGL)

Alphabet rose 2% in post-market trading after Google unveiled Gemini 4 Argon, its next-generation flagship AI model. The release follows weeks of anticipation and signals accelerated model deployment across Google Cloud and enterprise AI workflows, boosting investor sentiment around Alphabet’s proprietary AI stack and infrastructure positioning.

Micron Technology (MU)

Micron Technology jumped 2% after delivering a massive fiscal Q4 beat-and-raise report.

Candel Therapeutics, Inc. (Nasdaq: CADL) announced clinical and biomarker data from its phase 3 PrTK03 and phase 2 PrTK05 trials evaluating aglatimagene besadenovec in patients with intermediate-risk localized prostate cancer, according to a company press release.

In the PrTK03 phase 3 trial, 635 patients with intermediate-risk disease treated with aglatimagene plus external beam radiation therapy (EBRT) showed a 41% reduction in the risk of prostate cancer recurrence or prostate cancer-specifi

Investing.com -- Rafael Holdings Inc Class B (NYSE: RFL) shares fell 25% in premarket trading Wednesday after the company's Phase 3 trial of Trappsol Cyclo for Niemann-Pick Disease Type C failed to meet its primary endpoint.

The TransportNPC study, which enrolled 94 patients, showed Trappsol Cyclo did not achieve statistical significance on the primary endpoint of change in the 4-domain NPC Clinical Severity Scale at Week 96. The drug demonstrated a directionally favorable treatment effect vers

Investing.com -- Sagimet Biosciences Inc Series A (NASDAQ: SGMT) shares rose over 12% in premarket trading Wednesday following positive 52-week results from its license partner Ascletis' Phase 3 open-label extension trial of denifanstat for moderate to severe acne.

The trial showed denifanstat achieved a 57% treatment success rate, with a 72% reduction in total lesions and 77% reduction in inflammatory lesions after 52 weeks of treatment. The drug was generally well-tolerated, with no adverse e

Theriva Biologics (NYSE American: TOVX) announced that results from its VIRAGE Phase 2b clinical trial of VCN-01 (zabilugene almadenorepvec) in metastatic pancreatic cancer patients were published in Nature Medicine, according to a company statement.

The trial enrolled 112 patients across 14 sites in the U.S. and Spain. Patients in the VCN-01 treatment arm received intravenous VCN-01 seven days prior to the first and fourth cycles of standard-of-care gemcitabine/nab-paclitaxel chemotherapy. The

Merck (MRK) announced results from a Phase 2b trial of tulisokibart, an investigational monoclonal antibody, in patients with moderate to severe hidradenitis suppurativa (HS), a chronic inflammatory skin disease. The data were presented at the European Academy of Dermatology and Venereology 2026 Congress.

The trial, designated MK-7240-012, met its primary endpoint of HiSCR50 — a 50% reduction in abscesses and inflammatory nodules — at week 16. In the high-dose group (480 mg every two weeks), 72

INDIANAPOLIS - Eli Lilly and Company (NYSE:LLY) announced today that its drug Ebglyss met primary and secondary endpoints in a Phase 3b clinical trial for patients with moderate-to-severe hand and foot atopic dermatitis, according to a press release statement.

The ADtouch study evaluated 221 adults and adolescents who received either Ebglyss or placebo every two weeks for 16 weeks. At Week 16, 53% of patients treated with Ebglyss achieved clear or almost clear skin on hands and feet, compared t

CAMBRIDGE, Mass. - Sarepta Therapeutics Inc. (NASDAQ:SRPT) presented data on Wednesday showing functional outcomes for its gene therapy Elevidys in ambulatory Duchenne muscular dystrophy patients aged 8 to 12 years at the World Muscle Society Congress.

The analysis compared 25 treated patients from the EMBARK and ENDEAVOR studies with 99 patients from external control datasets. At two years, treated patients showed a 3.32-point difference in North Star Ambulatory Assessment scores compared to t

Candel Therapeutics, Inc. (Nasdaq: CADL) announced clinical and biomarker data from its phase 3 PrTK03 and phase 2 PrTK05 trials evaluating aglatimagene besadenovec in patients with intermediate-risk localized prostate cancer, according to a company press release.

In the PrTK03 phase 3 trial, 635 patients with intermediate-risk disease treated with aglatimagene plus external beam radiation therapy (EBRT) showed a 41% reduction in the risk of prostate cancer recurrence or prostate cancer-specifi

Investing.com -- Sagimet Biosciences Inc Series A (NASDAQ: SGMT) shares rose over 12% in premarket trading Wednesday following positive 52-week results from its license partner Ascletis' Phase 3 open-label extension trial of denifanstat for moderate to severe acne.

The trial showed denifanstat achieved a 57% treatment success rate, with a 72% reduction in total lesions and 77% reduction in inflammatory lesions after 52 weeks of treatment. The drug was generally well-tolerated, with no adverse e

Theriva Biologics (NYSE American: TOVX) announced that results from its VIRAGE Phase 2b clinical trial of VCN-01 (zabilugene almadenorepvec) in metastatic pancreatic cancer patients were published in Nature Medicine, according to a company statement.

The trial enrolled 112 patients across 14 sites in the U.S. and Spain. Patients in the VCN-01 treatment arm received intravenous VCN-01 seven days prior to the first and fourth cycles of standard-of-care gemcitabine/nab-paclitaxel chemotherapy. The

Investing.com -- Rafael Holdings Inc Class B (NYSE: RFL) shares fell 25% in premarket trading Wednesday after the company's Phase 3 trial of Trappsol Cyclo for Niemann-Pick Disease Type C failed to meet its primary endpoint.

The TransportNPC study, which enrolled 94 patients, showed Trappsol Cyclo did not achieve statistical significance on the primary endpoint of change in the 4-domain NPC Clinical Severity Scale at Week 96. The drug demonstrated a directionally favorable treatment effect vers

Merck (MRK) announced results from a Phase 2b trial of tulisokibart, an investigational monoclonal antibody, in patients with moderate to severe hidradenitis suppurativa (HS), a chronic inflammatory skin disease. The data were presented at the European Academy of Dermatology and Venereology 2026 Congress.

The trial, designated MK-7240-012, met its primary endpoint of HiSCR50 — a 50% reduction in abscesses and inflammatory nodules — at week 16. In the high-dose group (480 mg every two weeks), 72

INDIANAPOLIS - Eli Lilly and Company (NYSE:LLY) announced today that its drug Ebglyss met primary and secondary endpoints in a Phase 3b clinical trial for patients with moderate-to-severe hand and foot atopic dermatitis, according to a press release statement.

The ADtouch study evaluated 221 adults and adolescents who received either Ebglyss or placebo every two weeks for 16 weeks. At Week 16, 53% of patients treated with Ebglyss achieved clear or almost clear skin on hands and feet, compared t